[vc_empty_space][vc_empty_space]
Binding of nickel(II) tetrakis(dimethylpyrazolium-4-yl) porphyrin to poly(dG-dC) 2 and poly(dA-dT) 2
Tjahjono D.H.a, Suhendara, Permana B.a, Yoshioka N.b, Inoue H.b
a School of Pharmacy, Bandung Institute of Technology, Indonesia
b Department of Applied Chemistry, Keio University, Japan
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]The interaction of nickel(II) complex of cationic porphyrins bearing five-membered rings, meso-tetrakis(1,2-dimethylpyrazolium-4-yl) porphyrinatonickel(II) (NiPzP), with synthetic polynucleotides poly(dG-dC) 2 and poly(dA-dT) 2 has been characterized by viscometric, visible absorption, CD and MCD spectroscopic, and melting temperature measurements. The nickel(II) complex NiPzP is intercalated into poly(dG-dC) 2 but outside bound to the major groove of poly(dA-dT) 2. The binding constants of NiPzP to poly(dG-dC) 2 and poly(dA-dT) 2 are in the order of 10 6 M -1 and comparable to those of other reported cationic metalloporphyrins. The binding process of NiPzP to poly(dG-dC) 2 and poly(dA-dT) 2 is endothermic and entropically driven. Copyright © 2010 World Scientific Publishing Company.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Metallopyrazolium-4-ylporphyrin,Poly(dA-dT) 2,Poly(dG-dC) 2,Porphyrin-DNA interaction,Thermodynamic parameters[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]This research was supported in part by a Grant-in-Aid for Scientific Research (No. 13554025) from the Ministry of Education, Science, Sports, and Culture of the Japanese Government, KK ITB Research Grant 2007, Competitive Research Grant (HB XVI/2008) and Competence Grant 2009 from the Ministry of National Education of the Indonesian Government. D.H.T. wishes to thank The Hitachi Scholarship Foundation, Tokyo, Japan for financial support through the Hitachi Research Fellowship 2008.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.1142/S1088424610002148[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]