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Clinical study of turmeric (Curcuma longa L.) and Garlic (Allium sativum L.) extracts as antihyperglycemic and antihyperlipidemic agent in type-2 diabetes-dyslipidemia patients
Sukandar E.Y.a, Permana H., Adnyana I.K.a, Sigit J.I.a, Ilyas R.A.c, Hasimun P.a, Mardiyah D.a
a School of Pharmacy, Bandung Institute of Technology, Indonesia
b Endocrinology, Hasan Sadikin Hospital, Teaching Hospital of University Padjadjaran Bandung, Indonesia
c Innogene Kalbiotech Pte. Ltd., Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Turmeric (Curcuma longa L.) and garlic (Allium sativum Lin.) are known as traditional drugs that can cure several diseases such as dyslipidemia and diabetes. Many studies on individual usages of garlic and turmeric have been done previously. Present preclinical study showed that combination of both substances gave a better result compared to their individual usage. This research was aimed to evaluate the efficacy and safety of turmeric and garlic extracts combination as antihyperglycemic and antihyperlipidemic agents for type-2 diabetes-dyslipidemia. Three doses were evaluated: 1.2,1.6 and 2.4 g, daily. It was found that the garlic-curcuma combination could reduce plasma glucose level and HbA1C as well as improve the lipid profile. Among those 3 dosages, the dose of 2.4 g decreased fasting glucose level, 2 h postprandial glucose level, HbA1C, total cholesterol, low density lipoprotein, triglyceride and body mass index more than the two other dosages. This dose level also increased high density lipoprotein higher than the other two dosages. There was no significant adverse event observed during the study. The treatment also showed no side effect on kidney and liver functions as well as the blood composition of all subjects. © 2010 Asian Network for Scientific Information.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Antihyperglycemic,Antihyperlipidemic,Body mass index,Efficacy,Garlic,Turmeric[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.3923/ijp.2010.456.463[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]