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Antibacterial effect of component of Terminalia muelleri Benth. Against Staphylococcus aureus
Anam K.a,b, Suganda A.G.a, Sukandar E.Y.a, Kardono L.B.S.c
a School of Pharmacy, Bandung Institute of Technology, Indonesia
b Department of Chemistry, Diponegoro University, Indonesia
c Research Centre for Chemistry, Indonesian Institute of Sciences, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]A component of ethylacetate extract of Terminalia muelleri Benth. leaves, was found to inhibit Staphyloccoccus aureus and Methicillin-resistant Staphylococcus aureus growth therefore, the aims of this study were to investigate the effect of the active components on morphology of bacteria cell which was observed by Scanning Electron Microscope (SEM) and Transmission Electron Microscope (TEM). Tetracycline HCl, penicillin G and vancomycin HCl were used as reference antibiotic. The active component at twice of the MIC caused shrinkage and thinning of the cell wall. The cell damage pattern which is caused by the active compound was similar to the damage caused by vancomycin HCl. It was explained that the antibacterial target of action of the active compound was inhibit the synthesis of the cell wall. © 2010 Asian Network for Scientific Information.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Antibacterial,Cell wall,Electron microscope,Mode of action,Terminalia muelleri[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.3923/ijp.2010.407.412[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]