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Cocrystalline phase transformation of binary mixture of trimethoprim and sulfamethoxazole by slurry technique
Zaini E.a, Sumirtapura Y.C.a, Soewandhi S.N.a, Halim A.b, Uekusa H.c, Fujii K.c
a School of Pharmacy Institute Teknologi Bandung, Indonesia
b Faculty of Pharmacy, Universitas Andalas, Indonesia
c Department of Chemistry and Materials Science, Tokyo Institute of Technology, Japan
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]The purpose of this work was to characterize and investigate the transformation of cocrystalline phase in binary mixture of trimethoprim and sulfamethoxazole induced by slurry technique and to establish the rate of transformation at various temperatures. Cocrystallization was performed simply by adding distilled water as solvent to equimolar binary mixture of powder trimethoprim and sulfamethoxazole. A new solid phase was characterized by thermomicroscopy, scanning electron microscope, powder X-ray diffraction, differential scanning calorimetry. The rate of transformation in slurry was studied as function of storage temperature, measured by powder X-ray diffractometry. Physical characterization showed that the trimethoprim and sulfamethoxazole cocrystalline phase had a unique thermal, powder X-ray diffraction property. Cocrystals prepared by slurry technique were similar in PXRD pattern to those prepared by solvent methods. The transformation to cocrystalline phase was accelerated by increasing the temperature of storage. It could be concluded that slurry could be carried out to induce a new equimolar cocrystalline phase between sulfamethoxazole and trimethoprim. The rate of transformation to cocrystalline phase was affected by the temperature of storage.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Cocrystalline phase,Slurry technique and rate of transformation,Sulfamethoxazole,Trimethoprim[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]