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Chemical reactivity of chlorambucil in organic solvents: Influence of 4-chloro butyronitrile nucleophile to voltammogram profiles
Setiyanto H.a, Saraswaty V.b, Hertadi R.a, Noviandri I.a, Buchari B.a
a Analytical Chemistry Research Group, Faculty of Mathematics, Natural Sciences Institut Teknologi Bandung, Indonesia
b Research Centre for Chemistry, Indonesian Institute of Sciences Jl. Cisitu Sangkuriang, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Chlorambucil is one of anticancer drug that has been mainly used in the treatment of cancer disease. It is an alkylating agent and can be given orally. Interaction of chlorambucil in the presence of 4-chloro butyronitrile has not been studied electrochemically. We presented the investigation of electrochemical reduction and oxidation of chlorambucil in the presence of 4-chloro butyronitrile as a nucleophile in acetone and acetonitrile using cyclic voltammetry technique. The results showed that the value of chemical reactivities (Kf) of chlorambucil in such solution system was higher than that without the presence of 4-chloro butyronitrile as a nucleophile. We found that at working potential range of 0.8 V to 1.5 V and scan rates range of 0.1 Vsec-1 to 1 Vsec-1, the values of chemical reactivity of chlorambucil in acetone and acetonitrile, in the presence and absence of 4-chloro butyronitrile were 0.2715sec-1, 0.2676 sec-1 and 0.2248 sec-1, 0.0245 sec-1, respectively. These results indicated that the values of chemical reactivity of chlorambucil can be affected by the type of solvent used. In addition, the shift of these values were influenced by the presence of another nucleophile in solution i.e. 4-chloro butyronitrile. © 2011 by ESG.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Chemical Reactivity,Chlorambucil,Cyclic voltammetry,Organic solvent[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]