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The role of thiol on degradation of pentaerythrityl tetranitrate and isosorbide dinitrate
Suwitono M.R.a,b, Kartasasmita R.E.a, Pamudji J.S.a, Ibrahim S.a
a School of Pharmacy, Institut Teknologi Bandung, Indonesia
b Department of Science, Universitas of Advent Indonesia, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Thiols such as N-acetylcystein (NAC) are used to replenish glutathione (GSH) level, with regard to their function in the maintenance of cellular reduction-oxidation balance and control of oxidative stress. Thiols play a role in the reductive metabolism of nitrates to NO, an important signaling molecule in the cardiovascular system as well as other systems throughout the body. This study aimed to evaluate the influence of NAC on decomposition of different organic nitrate esters according to its potential i.e., pentaerythrityl tetranitrate (PETN) and isosorbide dinitrate (ISDN). The results showed that NAC gives a rapid and significant decrease of PETN and ISDN during the incubation period. During the experiment, about 85% of PETN were decomposed, while the decomposition of ISDN was about 20%. Detection of nitrite and elucidation of disulphide bond of NAC gives evidence that confirms the presence of reactions. © 2011 Asian Network for Scientific Information. © 2011 Asian Network for Scientific Information.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Isosorbide and dinitrate,N-acetylcystein,Pentaerythrityl tetranitrate[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.3923/jas.2011.3854.3859[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]