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Combination of inulin-shellac as a unique coating formulation for design of co-lonic delivery dosage form of ibuprofen
Rachmawati H.a, Mudhakir D.a, Kusuma J.a
a School of Pharmacy, Institute of Teknologi Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]A combination of inulin and shellac, when applied as a film coat, has a potential value as a colon-specific delivery system for ibuprofen. The inulin-based multiunit pellet system is prepared by coating inulin and shellac sequentially around drug-loaded cores in a fluid-bed coater. The outer shellac coating protects the system against gastrointestinal environment and dissolves rapidly in small intestine, where a lumen pH around 7 triggers the dissolution of the enteric polymer. The inner inulin coating works as a time-controlled retardant and offers additional protection of the pellets until it is degraded by microbial enzymes at the colon region. In vitro data indicates that inulin is a promising coating material to obtain timed and enzyme-triggered ibuprofen release. Pharmacokinetic study in New Zealand rabbit confirmed the in vitro data and revealed a delayed absorption of about 3 h but with higher AUC. This result suggests that inulin-shellac system shows potential materials to provide a microbial triggered drug in the colon compartment. The higher AUC of ibuprofen from double coated pellet dosage form may indicate that absorption of ibuprofen in colonic compartment is more extensive than in gastric. © JK Welfare & Pharmascope Foundation.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Ibuprofen,Inulin,Microbe-dependent colonic release,Pellet,Pharmacokinetic profile,Shellac[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]