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Heating effect on the solid characteristics and solubility of anti-HIV didanosine
Alatas F.a,b, Soewandhi S.N.a, Sasongko L.a, Ismunandara
a School of Pharmacy, Bandung Institute of Technology, Indonesia
b Department of Pharmacy, Faculty Mathematics and Natural Sciences, University of Jenderal Achmad Yani, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Didanosine (2′,3′-dideoxyinosine) is a synthetic analogue of dideoxy purine nucleoside inosine has been reported to inhibit the replication of human immunodeficiency virus (HIV). Heating effect on the solid characteristics of anti-HIV didanosine has been studied by various methods. The aim of this work was to investigate the solid-state properties and the solubility in water of didanosine due to heating. Crystal habit of didanosine was heated and allowed to melt. The whole change was observed under a polarizing microscope equipped with a camera and heater. Didanosin were stored in oven at 60°, 150° and 200°C for 1 hour. The resulting samples were characterized by powder x-ray diffractometer (PXRD), differential scanning calorimeter (DSC), Fourier transform infrared (FTIR), and scanning electron microscopy (SEM). Solid characterization of didanosine after heating at 60°C and 150°C for 1 hour by PXRD, DSC, FTIR, and SEM showed that there were not significant differences with didanosine without heating. Solubility experiments showed that solubility of didanosine in water increase after heating at 60°C and 150°C for 1 hour. Didanosine after heating at 200°C showed the lower solubility. The PXRD, DSC, FTIR, and SEM showed that heating of didanosine at 200°C causes the formation of a new crystal structure which allegedly is its main degradation product, hypoxanthine.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Didanosine,DSC,Heating,PXRD,Solid characterization[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]