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Characterization of physical properties and dissolution rate of binary systems erythromycin stearate-microcrystalline cellulose and spray dried lactose due to compression forces
Setyawan D.W.I.a,b, Sumirtapura Y.C.a, Soewandhi S.N.a, Daryono Hadi T.J.a
a School of Pharmacy, Bandung Institute of Technology, Indonesia
b Faculty of Pharmacy, Airlangga University, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Physical properties and dissolution rate of binary system erythromycin stearate (ERS): microcrystalline cellulose (MCC) and spray dried lactose (SDL) due to compression forces had been studied using X-ray powder diffraction (XRPD), differential thermal analysis (DTA), scanning electron microscope (SEM) and dissolution test. ERS:MCC and ERS:SDL with a ratio of 90:10, 80:20 and 70:30 (w/w) were compressed by hydraulic press plain flat punches with a diameter of 13 mm and compression force of 29.5 kN. The main peaks X-ray powder diffraction positions at 5.7 and 10.5° were used to calculate the values of peak broadening, crystallite size and crystal orientation using the WinPlotr. Peak broadening was calculated from the full width at half maximum (FWHM). The FWHM values of binary system became higher as the amount of excipient increased, crystallite size and intensity of X-ray diffraction decreased compared to ERS. Phase diagram of the physical mixture shows the binary system ERS:MCC and ERS:SDL has no interaction, each individually melted in accordance with the melting point. From the results of scanning electron micrograph, it was known that the MCC and SDL dispersed among ERS which plastic deformation. ERS:MCC was rougher than the ERS:SDL. Enthalpies value decreases with increased amount of ERS. The result of dissolution test showed that the dissolution rate of ERS:MCC is faster than the ERS:SDL.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Compression force,Dissolution rate,Erythromycin stearate,Microcrystalline cellulose,Physical properties,Spray dried lactose[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]