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Dissolution improvement of ketoprofen tablets by solid dispersion method
Mauludin R.a, Pamudji J.S.a, Ruyanti D.a
a School of Pharmacy, Bandung Institute of Technology, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Ketoprofen is practically water-insoluble drug and has low bioavailability. A solid dispersion method is one of the methods to increase the solubility of an active pharmaceutical ingredient in water. The aims of this study are to develop a solid dispersion of ketoprofen using PVA (polivinil alcohol), hydrolyzed PVA and the mixture of PVP K-25 (polyvinylpyrrolidone K-25) with lactose and to evaluate dissolution profile and solubility of ketoprofen solid dispersion. In addition, influence of the tableting processes of ketoprofen solid dispersion loaded tablets is also studied to their dissolution profile. Solid dispersions were prepared by solvent-evaporation technique. Ketoprofen was mixed with PVA and hydrolyzed PVA at ratio 4:1 also with combination of PVP K-25 and lactose at ratio 4:1:3. Solubility and dissolution profile of the solid dispersions were evaluated. Futhermore the solid dispersions were also characterized by scanning electron microscope (SEM), and X-ray difractometry (XRD). Then all obtained solid dispersions were incorporated into tablets using wet granulation and direct compression methods. The solid dispersion can improve the solubility of ketoprofen and its rate dissolution. The highest increasing of solubility was revealed by hydrolyzed PVA solid dispersion (1.71 times). The alteration on the crystallinity of ketoprofen in all solid dispersions polymer were characterized by SEM and XRD. The highest rate dissolution was showed by hydrolyzed PVA solid dispersion, followed by PVA solid dispersion, and the combination of PVP K-25 with lactose. The dissolution profiles of solid dispersions were better than physical mixture and pure ketoprofen. The dissolution rate of ketoprofen from solid dispersions tablet were faster than the pure ketoprofen tablet. The preparation of ketoprofen solid dispersion tablets was not affect to their dissolution rate.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Dissolution,Ketoprofen,Solid dispersion,Tableting process[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]