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Simultaneous determination of didanosine and nicotinamide in binary mixture by first derivative uv spectrophotometry
Alatas F.a,b, Soewandhi S.N.a, Sasongko L.a, Ismunandara
a School of Pharmacy, Bandung Institute of Technology, Indonesia
b Department of Pharmacy, Faculty Mathematics and Natural Sciences, University of Jenderal Achmad Yani, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]A simple, rapid, precise, accurate and cost effective first derivative UV spectrophotometric method was developed for the determination of didanosine (DDI) and nicotinamide (NCT) in binary mixture without using any chemical separation step. The wavelengths at 260.8 nm for DDI and at 223.2 nm for NCT were the optimum working wavelengths for their determination without mutual interference. Linearity was obtained in the concentration range of 6-16 μg/mL for both drugs. Limit of detection and limit of quantitation of DDI at 260.8 nm were 0.33 and 1.01 μg/mL, respectively, while limit of detection and limit of quantitation of NCT at 223.2 nm were 0.48 and 1.44 μg/mL, respectively. The proposed procedure was successfully applied to the simultaneous determination of DDI and NCT in binary mixture with a good precision and accuracy.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Didanosine,First derivative UV spectrophotometric,Nicotinamide[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]