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Effect of iontophoresis and penetration enhancers on the in vitro diffusion of a piroxicam gel
Wathoni N.a, Pamudji J.S.b, Darijanto S.b
a Pharmaceutic Department, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
b School of Pharmacy, Institut Teknologi Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]The stratum corneum behaves as a barrier for most of drugs percutaneous absorption into the body. The ability of drug to penetrate the stratum corneum can be improved by using physical and chemical methods. The purpose of this study is to determine the effect of penetrance enhancers addition and application of iontophoresis method on diffusion of piroxicam gel preparation in vitro. The study was performed with flow through method for 6 hours using porcine ears skin as a diffusion membran; ethanol, ethyl acetate, tween 80 and dimethyl sulfoxide (DMSO) as penetrance enhancers; and 0.5 mA/cm2 constant current for iontophoresis method. The result showed that the piroxicam diffusions from the formula with penetrance enhancer were: F1 (ethanol 5%) > F3 (ethyl acetate 5%) > F4 (Tween 80 5%) > F2 (DMSO 5%) > FS (without penetrance enhancer) respectively. The amount of drug diffused by iontophoresis method was twice higher than in original formula (FS) without iontophoresis. The combination effect of penetrance enhancer and iontophoresis showed a better synergic effect in the formula F1 and F3, while in F2 and F4 was unclear.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Difussion,Dimehtylsulfoxide,Ethanol,Ethyl acetate,Iontophoresis,Penetration enhancer,Piroxicam,Tween 80[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]