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Biological evaluations of protoporphyrin IX, pheophorbide a, and its 1-hydroxyethyl derivativess for application in photodynamic therapy
Djalil A.D.a,b, Nurulita N.A.b, Limantara L.W.c, Ibrahim S.a, Tjahjono D.H.a
a School of Pharmacy, Bandung Institute of Technology, Indonesia
b Universitas Muhammadiyah Purwokerto, Indonesia
c Ma Chung Research Center for Photosynthetic Pigments, Universitas Ma Chung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Protoporphyrin IX (1), pheophorbide a (3), and its 1-hydroxyethyl derivativess (2,4) were studied in vitro as photosensitizer candidates for photodynamic therapy. Protoporphyrin IX has been indicated to have a cytotoxic effect in the absence of light excitation. The dark toxicity of 14 was evaluated against normal cells (Vero), human epithelial cervix carcinomas (HeLa) and human breast cancer (T47D) cell lines, while the phototoxicity of 1-4 was evaluated against HeLa and T47D cell lines. Moreover, the MTT assay was employed to evaluate cell viability. The 1-hydroxyethyl derivativess showed a lower dark toxicity in the three types of cells compared to the parent molecules. It was also observed that the parent molecules were more phototoxic than those of its 1-hydroxyethyl derivativess.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]1-hydroxyethyl derivativess,Pheophorbide a,Photodynamic therapy,Protoporphyrin IX[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]