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PVA-ketoprofen nanofibers manufacturing using electrospinning method for dissolution improvement of ketoprofen
Pamudji J.S.a, Khairurrijala, Mauludin R.a, Sudiati T.a, Evita M.a
a School of Pharmacy, Bandung Institute of Technology, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Ketoprofen is a NSAIDs agent which has analgesic and anti inflammation effects. Ketoprofen is classified into class II in the biopharmaceutical classification system that has high permeability but low solubility. Hence, the absorption rate of this substance is governed by its dissolution rate. Electrospinning is a method that combines solid dispersion technology and nanotechnology. This method can be selected to enhance the dissolution rate of active substances. The aim of this research is to improve the dissolution rate of ketoprofen through the preparation of polyvinyl alcohol (PVA) nanofibers containing ketoprofen using electrospinning process. Preparation of the nanofibers with various PVA-ketoprofen ratios, flow rates, and PVA concentrations in the solution was accomplished using electrospinning instrument. Casting solid dispersion film were also prepared by a solvent evaporation method and used as a reference. The dissolution rates of ketoprofen from nanofibers, casting films, and pure ketoprofen were conducted in HCl pH 1.2 medium at 37 °C. Characterization of nanofibers was carried out by using Scanning Electron Microscope (SEM) and X-ray Diffraction (XRD). Nanofibers with PVA/ketoprofen of 1:1 (in the ratio of w/w) showed a significant improvement in dissolution (p<0.05) compared to the pure ketoprofen. Meanwhile, nanofibers obtained from a solution containing 7.5 % PVA (w/v) and 4 ml/h in flow rate showed the best dissolution rate improvement and significantly different (p<0.05) with either the casting film or the pure ketoprofen. The improvement of ketoprofen dissolution was due to the increase of surface area of nanofibers and the change of ketoprofen from crystalline into amorphous form. The electrospinning technique can therefore be used to improve the dissolution rate of ketoprofen through the PVA-ketoprofen nanofibers formation by choosing the appropriate polymer concentration and manufacturing process. © (2013) Trans Tech Publications, Switzerland.[/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Author keywords" size="size-sm" text_align="text-left"][vc_column_text]Classification system,Electrospinning method,Electrospinning process,Electrospinning techniques,Ketoprofen,Poly (vinyl alcohol) (PVA),Polymer concentrations,Solvent evaporation method[/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Indexed keywords" size="size-sm" text_align="text-left"][vc_column_text]Dissolution,Electrospinning,Ketoprofen,Nanofibers,Poly (vinyl alcohol)[/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Funding details" size="size-sm" text_align="text-left"][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="DOI" size="size-sm" text_align="text-left"][vc_column_text]https://doi.org/10.4028/www.scientific.net/MSF.737.166[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]