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Physicochemical properties of hesperidin nanocrystal
Mauludin R.a,b, Muller R.H.a
a Department of Pharmaceutical Technology Biopharmaceutics, Nutri-Cosmetics Free University of Berlin, Germany
b School of Pharmacy, Bandung Institute of Technology, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Hesperidin nanocrystals was generated by high pressure homogenization. The physicochemical properties of a spray dried hesperidin nanocrystals were investigated including to re-dispersion, crystalline state, kinetic solubility, dissolution velocity. Hesperidin nanosuspension with concentration of 10% (w/v) was dried by a Mini Spray-dryer B-190. Photon correlation spectroscopy (PCS) and laser diffraction (LD) were employed to determine the particle size. DSC and X-ray diffraction were used to study crystalline state. The saturation solubility and dissolution were determined at certain time points at 25oC. Spray-dried hesperidin nanocrystals could be redispersed in water completely. The size average and polydispersity index (PI) were 396 nm and 0.555 after redispersion. The d50% of nanocrystals was 0.370 μm. The crystalline state showed that the high pressure homogenization process did not change the crystaline state. Saturation solubility of spray-dried hesperidin nanocrystals in water was 87.2 μg/ml and higher than hesperidin raw material. Hesperidin nanocrystals was dissolved completely within 15 minutes in various media. Whereas hesperidin raw materials after 15 minutes was dissolved maximum only 37%. Spray-dried hesperidin nanocrystals could provide superior physicochemical properties. Spray-dried hesperidin nanocrystals increased the saturation solubility and especially the dissolution velocity in comparison to raw material, i.e. drug delivery improved in case dissolution velocity is the rate limiting step.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Dissolution velocity,DSC,Hesperidin,Nanocrystals,Nanosuspension,Re-dispersion,Saturation solubility,Spray drying,X-ray[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]