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Preparation and storage stability of rutin nanosuspensions
Mauludin R.a,b, Muller R.H.a
a Department of Pharmaceutical Technology, Biopharmaceutics and NutriCosmetics, Free University of Berlin, Germany
b School of Pharmacy, Bandung Institute of Technology, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Formulations of the rutin nanosuspensions have been prepared by high pressure homogenization (HPH). A Micron LAB 40 was used for HPH to obtain rutin nanosuspensions. Photon correlation spectroscopy (PCS) and laser diffraction were employed to analyze the particle size. Morphology of the particles was analyzed by light microscopy. The HPH technique produced rutin nanosuspensions having PCS size average of 547-912 nm and zeta potential range about -30 mV in water. Aqueous rutin nanosuspension stabilized by SDS and Tween 80 were stable over 12 months. The nanosuspensions produced via HPH not only could prevent large particle size and particle growth, but also protect the drugs from chemically degradation. The molecules of the surface stabilizer are able to shield the chemical compound. The crystalline structure in a nanoparticulate sized formulation results in improved drug chemical-stability. © 2013 The Korean Society of Pharmaceutical Sciences and Technology.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Chemical stability,Nanosuspensions,Physical stability,Rutin,Stabilizer[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]Acknowledgments This article dose not contain any studies with human and animal subjects performed by any of the authors. Those works were supported by Deutscher Akademischer Austauschdienst – DAAD (Kennziffer No. A/03/41167) and PharmaSol GmbH, Germany. Therefore authors (R. Mauludin and R. H. Muller) would like to say thank you for all those supports and report no conflict of interest.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.1007/s40005-013-0084-1[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]