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Synthesis of selective molecularly imprinted polymer for solid-phase extraction of glipizide by using a pseudo-template
Kartasasmita R.E.a, Hasanah A.N.a,b, Ibrahim S.a
a School of Pharmacy, Bandung Institute of Technology, Indonesia
b Universitas Padjadjaran, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Selective molecularly imprinted polymers (MIPs) for solid-phase extraction and determination of glipizide have been designed and prepared. MIPs were synthesized with acrylamide as the functional monomer and ethyleneglycoldimethacrylate as the cross-linker in chloroform as a porogenic solvent by using bulk polymerization method. MIPs are able to bind 100% glipizide in chloroform by using a batch method compared to a non-imprinted one. By using Fourier Transform Infra Red, it was found that hydrogen bonding occurred between the carbonyl group of acrylamide and the proton donor of template. These results find the opportunity for this MIP to be used as an alternative of the pretreatment method before determination of glipizide by using glibenclamide as a pseudotemplate.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Glipizide,Molecularly Imprinted Polymer,Pseudo-template,Solid-phase extraction,Sulfonylurea drugs[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Glipizide,Molecularly imprinted polymer,Pseudo-template,Solid-phase extraction,Sulfonylurea drugs[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]