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Antidiabetic activity of aqueous leaf extracts of Guazuma ulmifolia Lamk., ethanolic extracts of Curcuma xanthorrhiza and their combinations in alloxan-induced diabetic mice
Adnyana I.K.a, Yulinah E.a, Yulieta, Kurniati N.F.a
a School of Pharmacy, Institute Technology Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Guazuma ulmifolia Lamk. and Curcuma xanthorrhiza are traditionally used to treat diabetes mellitus and are having potential in the development of drug for diabetes due to their antidiabetic activity. Therefore, this study aimed to evaluate the antidiabetic activity of aqueous leaf extracts of Guazuma ulmifolia Lamk. and ethanolic extracts of Curcuma xanthorrhiza and their combinations in alloxan-induced diabetic mice. Aqueous leaf extracts of Guazuma ulmifolia Lamk., ethanolic extracts of Curcuma xanthorrhiza and its combinations were administered orally to Swiss Webster mice. Alloxan was used to induce diabetes mellitus. The parameters studied included oral glucose tolerance test, blood glucose serum level of alloxan induced diabetic mice and histology of pancreatic cells. The results showed that in oral glucose tolerance test and alloxan-induced diabetic mice, plasma glucose level in both extracts studied and their combinations were significantly lower than positive control, suggesting a potential effect as antidiabetic. By the histology study, combination of G. ulmifolia at dose of 25 mg kg-1 b.wt. and C. xanthorrhiza at dose of 12.5 mg kg-1 b.wt. (the lowest combination) showed less damage of pancreatic cells. The results suggest that Guazuma ulmifolia Lamk. and Curcuma xanthorrhiza has an antidiabetic activity, probably by increasing insulin production, thereby justifying its traditional claim. © 2013 Academic Journals Inc.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Alloxan,Antidiabetic,Curcuma xanthorrhiza,Guazuma ulmifolia Lamk.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.3923/rjmp.2013.158.164[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]