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Variation of the crystal growth of mesoporous silica nanoparticles and the evaluation to ibuprofen loading and release
Kamarudin N.H.N.a, Jalil A.A.a, Triwahyono S.a, Artika V.a, Salleh N.F.M.a, Karim A.H.a, Jaafar N.F.a, Sazegar M.R.a, Mukti R.R.b, Hameed B.H.c, Johari A.a
a Institute of Hydrogen Economy, Department of Chemical Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81310 UTM Skudai, Malaysia
b Division of Inorganic and Physical Chemistry, Faculty of Mathematics and Natural Science, Institut Teknologi Bandung, Indonesia
c School of Chemical Engineering, Engineering Campus, Universiti Sains Malaysia, Malaysia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Mesoporous silica nanoparticles (MSNs) were synthesized with variable microwave power in the range of 100-450W, and the resulting enhancement of MSN crystal growth was evaluated for the adsorption and release of ibuprofen. X-ray diffraction (XRD) revealed that the MSN prepared under the highest microwave power (MSN450) produced the most crystallized and prominent mesoporous structure. Enhancement of the crystal growth improved the hexagonal order and range of silica, which led to greater surface area, pore width and pore volume. MSN450exhibited higher ibuprofen adsorption (98.3mg/g), followed by MSN300(81.3mg/g) and MSN100(74.1mg/g), confirming that more crystallized MSN demonstrated higher adsorptivity toward ibuprofen. Significantly, MSN450 also contained more hydroxyl groups that provided more adsorption sites. In addition, MSN450 exhibited comparable ibuprofen adsorption with conventionally synthesized MSN, indicating the potential of microwave treatment in the synthesis of related porous materials. In vitrodrug release was also investigated with simulated biological fluids and the kinetics was studied under different pH conditions. MSN450showed the slowest release rate of ibuprofen, followed by MSN300 and MSN100. This was due to the wide pore diameter and longer range of silica order of the MSN450. Ibuprofen release from MSN450 at pH 5 and 7 was found to obey a zero-order kinetic model, while release at pH 2 followed the Kosmeyer-Peppas model. © 2014 Elsevier Inc.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Adsorption,Anti-Inflammatory Agents, Non-Steroidal,Crystallography, X-Ray,Drug Carriers,Hydrogen-Ion Concentration,Ibuprofen,Microscopy, Electron, Scanning,Nanoparticles,Silicon Dioxide[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Drug delivery,Ibuprofen,Mesoporous silica nanoparticles,Microwave,PH[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]The authors are grateful for the financial support by the Research University Grant from Universiti Teknologi Malaysia (Grant No. 02H76), the awards of MyPhD Scholarship (Nur Hidayatul Nazirah Kamarudin) from Ministry of Higher Education, Malaysia, and to the Hitachi Scholarship Foundation for their support.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.1016/j.jcis.2014.01.034[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]