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In vitro evaluation of xanthine oxidase inhibitory activity of Sonchus arvensis leaves
Hendriani R.a,b, Sukandar E.Y.a, Kusnandaranggadiredjaa, Sukrasnoa
a School of Pharmacy, Bandung Institute of Technology, Indonesia
b Universitas Padjadjaran, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Objective: This studyexaminedthe inhibiting effects of different extracts of S.arvensis leaves onthe activity of xanthine oxidase, an essential enzyme for uric acid synthesis. Methods: Activity test was conducted in vitro by measuring the activity of xanthine oxidase using UV spectrophotometry. Results: The IC50 of ethanolic extract of S. arvensis leaves was 23.64 μg/mL. Meanwhile, the n-hexane, ethylacetateandwater fraction of the extract had respective IC50 of 263.19, 16.20 and 141.80 μg/mL. When the leaves were extracted with ethyl acetate, the extract thus obtained showed an IC50of 15.29 μg/mL.Allopurinol, as reference drug, had IC50 of 4.84 μg/mL. Conclusion: Ethyl acetate extract of S. arvensis leaves potential to be developed as agent to treat hyperuricemia and gout.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Gout,In vitro,Inhibitory effect,Sonchusarvensis,Xanthine oxidase[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]