2-s2.0-84898447401

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[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Objective: The formula of curcumin nanoemulsion had been established in our previous research. Encapsulation of curcumin in this nanocarrier system is expected to increase the bioavailability of the curcumin after oral administration, hence giving better effects. The objective of this study is to formulate tablet containing curcumin nanoemulsion for oral delivery. Methods: The formulation of curcumin nanoemulsion was done by using oil phase: glycerylmonooleate, cremophor RH 40 as surfactant and polyethylene glycol 400 as co-surfactant in the ratio of 1:8:1, and was dispersed in water with mild stirring. Tablet was produced by wet granulation method, using 9% PEG 6000 as lubricant, polyvinylpyrrolidone 5% as binder, mannitol as filler, 1% sodium chloride as glidant and 2% sodium lauryl sulphate as lubricant. Tablet evaluation was performed according to standard quality of tablet. Results: Curcumin nanoemulsion with particle size of 125.7± 1.029 nm and percentage of drug encapsulated of 99.52% was formed. Tablet containing this nanoemulsion has good physical characteristics with hardness of 5.95 kg/cm2 and 99.79% of curcumin dissolved in 60 minutes. Curcumin nanoemulsion formulated into tablet dosage form still maintained the particle size of 134±1.45 nm when the tablet was dispersed in water. Conclusion: Taken together, curcumin nanoemulsion was able to be formulated into solid dosage form, resulting good physical characteristic of the tablet while maintaining the nanoemulsion form when the tablet was dispersed in water. The comparison of the dissolution profile between tablet curcumin and tablet containing curcumin nanoemulsion should be done to ensure that the tablet formulation using curcumin nanoemulsion is better.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Curcumin,SNEDDS,Tablet,Transformation,Wet granulation[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]