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Anti-obesity effect of the pomegranate leaves ethanol extract (Punicagranatuml.) in high-fat diet induced mice
Adnyana I.K.a, Sukandar E.Y.a, Yuniarto A.a,b, Finna S.a
a Pharmacology and Clinical Pharmacy Research Group, School of Pharmacy, Institut Teknologi Bandung (ITB), Indonesia
b Department Pharmaceutics, Universitas Airlangga (Unair), Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Objective: The aim of the study was to evaluate in vivo and in vitro assay from the pomegranate leaves ethanol extract (PLEE)as the anti-obesity. Methods: The anti-obesity effect was evaluated to in vivo model high-fat diet induced obese mice and used two doses level 50 mg/kg and 100 mg/kg b.w. from the extract. In vitro assay was measured through inhibitory effect of pancreatic lipase enzyme activity by pomegranate leaves ethanol extract with various concentrations. Results: The pomegranate leaves ethanol extractat a dose 50 mg/kg and 100 mg/kgb.w. showed asignificant decrease of body weight, faeces index, total fat index, food index, and lee’s index compared to control mice. Furthermore, significantly inhibitory activity also showed from in vitro assay. Conclusion: The pomegranate leaves ethanol extract may be a potentially therapeutic alternative in the treatment of obesity caused by a high-fat diet.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Anti-obesity,High fat diet,Pancreatic lipase enzyme,Pomegranate leaves ethanol extract[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]