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Acute and sub chronic toxicity study of ethanol extract of anredera cordifolia (Ten.) v. steenis leaves
Salasanti C.D.a, Sukandar E.Y.a, Fidrianny I.a
a School of Pharmacy, Bandung Institute of Technology, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Objectives: To evaluate acute and sub chronic oral toxicity effects of ethanol extract of Anredera cordifolia (Ten.) v. Steenis leaves. Methods: Extract was prepared by reflux method in ethanol 96%. Acute oral toxicity test was conducted in ddY mice using the conventional test. A. cordifolia extract was administered orally at dose ranging between 0.05 – 15 g/kg body weight to experimental mice and observed for any toxic symptoms up to 14 days. Sub chronic toxicity study was evaluated in Wistar albino rats by administration orally A. cordifolia extract at doses of 0.1 g/kg body weight, 0.4 g/kg body weight, and 1 g/kg body weight daily for 90 days. Behavior, mortality, and body weight of rats were observed during study period. Relative organ weight, hematology, blood biochemistry, and histopathology were observed at the end of study period. Results: The A. cordifolia extract was well tolerated at the single administration in acute toxicity study. No mortality was observed even at the highest dose of 15 g/kg body weight. In sub chronic toxicity study, A. cordifolia extract up to dose of 1 g/kg body weight did not cause mortality and behavioral changes. There were no significantly different in body weight development, relative organ weight, hematology, blood biochemistry in rats treated by A. cordifolia extract compared with control group (p > 0.05). Histology observations showed that heart, lung, liver, kidney and spleen had no different with the control group. Conclusion: Beside on acute and sub chronic study, ethanol extract of A. cordifolia leaves showed no toxic signs or abnormalities that can be considered to be safe for medical uses.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Acute,Anredera cordifolia,Oral toxicity,Sub chronic[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]