[vc_empty_space][vc_empty_space]
Xanthine oxidase inhibitory and immunomodulatory activities of fifteen grades Indonesia orthodox black tea
Rohdiana D.a,b, Suganda A.G.a, Wirasutisna K.R.a, Iwo M.I.a
a School of Pharmacy, Bandung Institute of Technology Jl, Indonesia
b Research Institute for Tea and Cinchona Gambung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Objective: to study the effect of fifteen grades Indonesian orthodox black tea as xanthine oxidase (XO) inhibitor and immunomodulator. Methods: Effect on XO activity was studied in vitro by using xanthine as a substrate. The degree of inhibition was determined by measuring the absorbance at 295 nm associated with uric acid formation. Effect of immune system was studied in vivo through carbon clearance test by determination of phagocytic index of reticulum endothelium system. Results: among the fifteen grades, Broken Orange Pekoe (BOP), Pekoe Fanning (PF), and Broken Pekoe (BP) have inhibition effect on XO activity with an inhibition percentage more than 50%. The highest XO inhibitory effect was showed by BOP with inhibition percentage of 61.58%. Study on immune system showed that BOP, PF, Dust, and BP grades had immunostimulating, effect with the highest value was shown by PF with a phagocytic index of 1. 41. Conclusion: among the fifteen grades of orthodox black tea: BOP, PF, and BP have XO inhibitory and immunomodulatory activities.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]15 grades of orthodox black tea,Immunomodulatory activity,Xanthine oxidase inhibitory[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]