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Acute and subchronic oral toxicity studies of ethyl acetate extract of sonchus arvensis L. leaves
Nurianti Y.a, Hendriani R.a, Sukandar E.Y.a, Anggadiredja K.a
a School of Pharmacy, Bandung Institute of Technology, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Objectives: To evaluate acute and subchronic oral toxicity of ethyl acetate extract of Sonchus arvensis L. leaves. Methods: Extract was prepared by maceration in ethyl acetate. Acute oral toxicity test was conducted in ddY mice using the conventional test. Sixty mice were divided into 6 groups, namely control group and five test groups, each given the extract at 0.19 g/kg body weight (b.w), 0.56 g/kg b.w, 1.67 g/kg b.w, 5 g/kg b.w and 15 g/kg b.w, respectively. Subchronic toxicity test was carried out in Wistar rat after daily administration of ethyl acetate extract of Sonchus arvensis L. leaves for 90 days at 100 mg/kg b.w, 400 mg/kg b.w, and 1000 mg/kg b.w. The rats in all groups were observed for behaviour, body weight development, haematological, clinical biochemistry, organ to body weight ratio, and organ histology. Results: No mortality was observed both in acute and subchronic toxicity test in male and female animals. Observed behaviour, body weight profile and organ histology among experimental groups were comparable. Haematological, clinical biochemistry parameters, organ to body weight ratio were not significantly different (p>0.05). Conclusion: There were no toxic effects after the use of single dose and repeated dose of ethyl acetate extract of Sonchus arvensis L. leaves in animal tested. Results of the present study suggest that ethyl acetate extract of Sonchus arvensis L. leaves is safe after single administration at high dose and repeated administration during 90 days.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Acute,Ethyl acetate extract,Oral toxicity,Sonchus arvensis L,Subchronic[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]