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Evaluation of teratogenicity effects of ethanolic extracts of binahong leaves (anredera cordifolia (ten) steenis) in wistar rat
Sukandar E.Y.a, Kurniati N.F.a, Fitria V.a
a Department of Pharmacology-Clinical Pharmacy, School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]©.2014, International Journal of Pharmacy and Pharmaceutical Science. All Right Reserved.Objective: The aim of this study was to evaluate teratogenicity effect of ethanolic extract of binahong (Anredera cordifolia (Ten.) Steenis) leaves in Wistar rats.Methods: The teratogenicity test were done in 5 groups of rat i. e. control group, trimethoprim at a dose of 360 mg/kg bw, ethanolic extract of binahong at doses of 100, 400, and 1000 mg/kg bw. Test substance was given orally on day 6 to day 15 of rats pregnancy. At day 20 of gestation, laparoctomy was performed to retrieve the fetuses. Evaluation was done towards the fetus skeletal, organ and fetal weight.Results: Teratogenicity test results showed that there was the ungrowth fetus observed in all groups with the highest incident in trimethoprim group (39.5%). Average of fetus body weight of trimethoprim, control, binahong extract at doses of 100, 400 and 1000 mg/kg bw group was 2.32 ± 0.66 g, 3.58 ± 0.24 g, 3.64 ± 0.26 g, 3.67 ± 0.25 g and 3.93 ± 0.61 g, respectively. Skeletal evaluation showed that there was malformation of sacral vertebrae (65.2%), convulated costal stucture (82.6%), palate (33.3%), head cavity (88.9%), nasal cavity (5.6%), eye cavity (5.6%), ear (5.6%) and liver (43.1%) which were observed only in trimethoprim group.Conclusion: Ethanolic extract of binahong at doses of 100, 400 and 1000 mg/kg bw in rat did not have the teratogenic effect.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Anredera cordifolia (ten.) steenis,Binahong,Teratogenic effect,Trimethoprim[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]