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The influence of formula and process on physical properties and the release profile of PVA/BSA nanofibers formed by electrospinning technique
Risdian C.a,b, Nasir M.b, Rahma A.a, Rachmawati H.a
a School of Pharmacy, Bandung Institute of Technology (ITB), Ganesha,Bandung, 40132, Indonesia
b Research Center for Chemistry, Indonesian Institute of Sciences (LIPI), Cisitu – Sangkuriang,Bandung, 40135, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© (2015) Trans Tech Publications, Switzerland.Electrospinning is a simple and versatile process to produce nanofibers. However, it requires careful approach to fabricate suitable fibers for different purposes. This report describes aspects influencing successful development of nanofiber containing BSA using electrospinning method. Optical and scanning electron microscopy, energy dispersive X-Ray and Fourier transformed infrared spectroscopy, differential scanning calorimetry, and X-Ray diffraction analysis of nanofiber were performed. Modification of PVA/BSA nanofiber with Eudragit L-100 was conducted by dip coating method. The presence of BSA increased the diameter of the fibers. Modification of PVA/BSA nanofiber with Eudragit L-100 delayed the release of BSA in acidic medium but promoting its release in intestinal mimicking medium.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Bovine serum albumins,Electrospinning method,Electrospinning techniques,Energy dispersive x-ray,Enteric release,Eudragit,Fourier transformed infrared spectroscopy,PVA[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Bovine serum albumin,Electrospinning,Enteric release,Eudragit L- 100.,nanofibers,PVA[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.4028/www.scientific.net/JNanoR.31.103[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]