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Anticancer screening of selected Apocynaceae, Simaroubaceae and Magnoliaceae of Indonesian plants using mechanism-based yeast bioassay
Zuhrotun A.a,b, Suganda A.G.b, Wirasutisna K.R.b, Wibowo M.S.b
a Universitas Padjadjaran, Indonesia
b School of Pharmacy, Institut Teknologi Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2015, Global Research Online. All rights reserved.National Cancer Institute recommends some plant families as Families Of Special Interest (FOSI) that predicts abundance of anticancer agents. In present study, some FOSI of Indonesian plants were screened by mechanism-based yeast bioassay for their anticancer activity. The research result revealed that 6 of 23 species of Apocynaceae, Simaroubaceae and Magnoliaceae were potential as anticancer agents, having DNA damaging agent or a Topoisomerase inhibitor. The best extract as anticancer agents was bark extracts of Funtumia elastic (Preuss) Stapf, Kibatalia arborea (Blume) G. Don and Michelia champaca L. that showed bioactivity on Saccharomyces cereviceae strain 1140 (Topoisomerase I inhibitor) with IC12 values at 1590.78, 1657.67, 3424.54 µg/mL, respectively and bioactivity on Saccharomyces cereviceae strain 1353 (Topoisomerase II inhibitor) with IC12 values at 353.42, 931.39, 2124.42 µg/mL, respectively. Camptothecin and Nystatin were used as reference anticancer and antifungal agent.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Anticancer agents,Apocynaceae,Indonesian plants,Magnoliaceae,Saccharomyces cereviceae,Simaroubaceae,Topoisomerase inhibitors[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]