[vc_empty_space][vc_empty_space]
Comparative study of kanamycin and capreomycin on serum potassium level of multidrug resistance tuberculosis patientsat a hospital in Bandung, Indonesia
Amalia L.a, Zulfa I.M.a, Soeroto A.Y.b
a Department of Pharmacology and Clinical Pharmacy, Bandung Institute of Technology (ITB), Bandung, Indonesia
b Division of Respirology and Critical Respiration Disease, Department of Internal Medicine, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2016 The Authors. Published by Innovare Academic Sciences Pvt Ltd.Objective: Kanamycin and capreomycin are the second lines injectable ant tuberculosis used in therapy regimen of multidrug resistance tuberculosis (MDR TB) in Indonesia. Both have effects on serum potassium levels and cause hypokalemia. The aim of this study is to compare and evaluate the effects of kanamycin and capreomycin on serum potassium levels of MDR TB patient. Methods: This was a retrospective and concurrent cohort study with intention-to-treat analysis on MDR TB patients during 2014 at Dr. Hasan Sadikin General Hospital Bandung, Indonesia. The patients were divided into two groups, one group received kanamycin regimen. Meanwhile, the other group received capreomycin regimen. Serum potassium level, the incidence of hypokalemia and the classification of its severity were compared monthly for five months of the therapy. Results: In the first two months, capreomycin significantly decreased serum potassium level stronger than kanamycin (2.95 mEq/l vs. 3.82 mEq/l, P<0.001 in the first month and 2.85 mEq/l vs. 3.81 mEq/l, P<0.001 in the second month). Before five months, the number of enabled patients to follow up decline which is caused by hypokalemia in capreomycin group was60.0% while in kanamycin group is 0.0%. Conclusion: Capreomycin has a stronger effect on decreasing serum potassium level compared to kanamycin, and it causes hypokalemia.[/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Author keywords" size="size-sm" text_align="text-left"][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Indexed keywords" size="size-sm" text_align="text-left"][vc_column_text]Adverse drug reaction,Hypokalemia,Second line injectable antituberculosis[/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Funding details" size="size-sm" text_align="text-left"][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="DOI" size="size-sm" text_align="text-left"][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width="1/4"][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]