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Subchronic toxicity study of corn silk (Zea mays l.) in combination with binahong (Anredera cordifolia (Ten.)) steenis leaves on wistar rats
Sukandar E.Y.a, Fidrianny I.a, Nofianti T.a, Safitri D.a
a Pharmacology and Clinical Pharmacy Research Group, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2016, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.Objective: Nowadays, modern medication has been shifting into natural-based medication. These phenomena lead to the elevation of the use of traditional medicine. Similar to modern medicine, nature-based medicine should meet the standard which is including safety, efficacy, and quality aspects. The medicine must be safe during the consumption period and scientifically proven through preclinical toxicity test. It can be obtained through acute and subchronic toxicity test. Besides, it should have abilities to treat certain diseases and ease of accessing such medicines should be guaranteed particularly for patients. From our previous study, a combination of ethanolic extract of corn silk (CS) and binahong leaves (BL) showed activity in ameliorating kidneys function on renal failure rat’s model. Therefore, to obtain standardized traditional medicine, a study on safety must be accomplished. Methods: A 90-day oral toxicity study using Wistar rats was conducted to evaluate subchronic toxicology. The combination of extracts were given in three different levels daily for 90 days and a 120 days toxicity test was carried out for satellite groups. Results: Administration of extracts in combination to rats for 90 days did not alter behavioral, motoric activities, urine, hematological, chemical, and histopathological parameters, and it was suggested a no-observed adverse-effect level of CS 450 mg/kg and BL 600 mg/kg in combination. Even though the number of white blood cells in all treated groups arose compared to the control group, but the values were still in the normal range. Conclusion: These results indicate that the combination of ethanolic extract of CS and BL can be generally meet safety requirement as traditional medicine.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Anredera cordifolia (Ten.) Steenis,Binahong leaves,Corn silk,Subchronic toxicity test,Zea mays L.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]