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Potential alpha-glucosidase inhibitor from selected zingiberaceae family
Hasimun P.a, Adnyana I.K.b, Valentina R.a, Lisnasari E.a
a Pharmacology Research Group, Bandung School of Pharmacy, Bandung, Indonesia
b Department of Pharmacology and Clinical Pharmacy Research Group, School of Pharmacy, ITB, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2016, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.Objective: This study aimed to evaluate Zingiberaceae family as potential sources of alpha-glucosidase inhibitors (AGIs). Methods: A 16 species of selected Zingiberaceae family were macerated by ethanol 96%. The extracts were filtered and concentrated by rotary evaporator. Phytochemical analysis carried out on the dry extract. AGI was assayed in 50 mM phosphate buffer at pH 6.8 with 5 mM p-nitrophenyl-α- D-glucopyranoside as the substrate. Alpha-glucosidase activity was determined by measuring the release of the yellow p-nitrophenol at 400 nm using a spectrophotometer UV-Vis, and the percentage of inhibition was calculated. Results and Conclusion: The Zingiberaceae family showed IC50 against alpha-glucosidase varies range from 28.4 μg/ml to 269.2 μg/ml. Curcuma longa L., Zingiber cassumunar Roxb., Curcuma heyneana Val. Et van zijp, Curcuma xanthorrhiza Roxb., Zingiber ottensii Val., showed the highest inhibition against alpha-glucosidase, with IC50 28.4, 49.0, 78.2, 78.9, and 79.0 μg/ml, respectively. The Zingiberaceae family is potential sources as an alternative medicine to treated diabetes mellitus.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Alpha-glucosidase inhibitor,Diabetes mellitus,Phytochemistry content,Zingiberaceae[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]