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Evaluation of teratogenic effect of tempuyung (Sonchus arvensis) extract on wistar rats
a Pharmacology and Clinical Pharmacy Research Group School of Pharmacy, Institut Teknologi Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2016, International Journal of Pharmacognosy and Phytochemical Research. All rights reserved.Objectives: this study was conducted to obtain safety data of ethanolic extract of tempuyung leaves (EETL) on pregnant Wistar rats. Methods: Four groups of rats were used for this study, including control group, ethanolic extract of tempuyung leaves (EETL) at doses of 100 mg.kg-1, 400 mg.kg-1 and 1000 mg.kg-1, in which each group consisted of ten pregnant rats. Extracts were administered once daily starting from day 6 to day 15 of pregnancy. At day 20 of gestation period, laparotomy was performed to isolate the fetuses. For evaluation, all parameters related to fetal state such as fetal appearances, skeletal condition, organ weight, as well as fetal weight were determined. Results: There was no difference between EETL treated group with the control group in parameters: fetal weight, organ weight, mortality rates, macroscopically fetal appearance, skeletal condition. Moreover, abnormalities of organs were not presented in all extract treated group. Conclusion: administration of EETL at doses of 100, 400 and 1000 mg.kg-1bw in rats did not show teratogenic effects.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Sonchus arvensis,Tempuyung leaves,Teratogenic effects[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]