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Anredera cordifolia leaves extract as antihyperlipidemia and endothelial fat content reducer in male wistar rat
Lestari D.a, Sukandar E.Y.a, Fidrianny I.a
a Pharmacology-Clinical Pharmacy Research Group, School of Pharmacy, Bandung Institute of Technology, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2015, International Journal of Pharmaceutical and Clinical Research. All rights reserved.The objective of this research was to evaluate antihyperlipidemia and endothelial fat content reducer of ethanol leaves extract of Anredera cordifolia (binahong) in male Wistar rat. The rats were given by high fat feed and pure cholesterol (on week 0, 3rd, 7th and 11th). The doses of binahong extract which was used in this study were 50 mg/kg body weight (bw), 100 mg/kg bw, 200 mg/kg bw. The result showed that blood cholesterol in statin group was decreased 75.85%, binahong leaves extract of 50, 100, 200 mg/kg bw decreased 55.29%, 63.45%, 67.70%, respectively, and 46.52% decreased in negative control group. Triglycerides was decreased 61.64% in statin group 41.08%, 47.59% and 50.66% in binahong leaves extract of 50, 100, 200 mg/kg bw respectively and 20.17% in negative control group, while LDL level decreased 97.14% in statin group, 81.31%, 89.01%, 95.33% in 50, 100, 200 mg/kg bw binahong extract, respectively and 69.69% in negative control group. On the other hand, it showed that no significantly increase in HDL level in all of extracts groups which were 2.93% 3.56% 3.66%, respectively in binahong leaves extract of 50, 100, 200 mg/kg bw, while HDL level in the statin group was increased 9.86%, and 1.63% in the negative control group. Binahong leaves extract with doses of 50 mg/kg bw, 100 mg/kg bw and 200 mg/kg bw, significantly reduced total cholesterol level, triglycerides, LDL level compared to negative control group (p< 0.05) and had no influence in HDL level. Binahong leaves extract with doses of 50,100 and 200 mg /kg bw could reduce fat deposits in the endothelial cell of blood vessels.[/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Author keywords" size="size-sm" text_align="text-left"][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Indexed keywords" size="size-sm" text_align="text-left"][vc_column_text]Anredera cordifolia,Anthyperlipidemia,Endothelial fat reducer[/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Funding details" size="size-sm" text_align="text-left"][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="DOI" size="size-sm" text_align="text-left"][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width="1/4"][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]