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Gas chromatograph-mass spectrometer analysis and acute oral toxicity of Cinnamomum burmannii., Ness Ex Bl. essential oil
Herdwiani W.a, Soemardji A.A.b, El-Fahmib, Tan M.I.b
a Department of Pharmacology, Faculty of Pharmacy, Setia Budi University, Surakarta, Indonesia
b Department of Pharmacology, School of Pharmacy, Bandung Institute of Technology, Bandung, 40132, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2016, Innovare Academics Sciences Pvt. Ltd. All rights reserved.Objective: Cinnamomum burmannii Nees Ex Bl. essential oil has cytotoxic effect on a lot of cancer cell lines. An investigation was carried out to analyze the possible chemical components from C. burmannii essential oil and evaluate its acute toxicity, before an effective formulation of C. burmannii essential oil as anticancer drugs. Methods: This study was analyzed chemical components from C. burmannii essential oil by gas chromatograph-mass spectrometer (GC-MS) and evaluated the acute oral toxicities of C. burmannii essential oil in strain Balb/C mice. Results: This analysis revealed that C. burmannii essential oil contains the active compound cinnamaldehyde (71.814%), trans-cinnamyl acetate (11.09%), coumarin (3.41%), and cineol (1.77%). Acute oral toxicity of C. burmannii essential oil with lethal dose 50 3679.11 mg/kg BW. Conclusion: C. burmannii essential oil contains the active compound cinnamaldehyde, trans-cinnamyl acetate, coumarin and cineol. Acute oral toxicity conclusively indicates C. burmannii essential oil includes category 5 practically non-toxic.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Acute toxicity,Cinnamomum burmannii,Essential oil,Gas chromatograph-mass spectrometer[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]