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Cell and molecular biology for diagnostic and therapeutic technology

Tan M.I.a

a School of Life Sciences and Technology, Institut Teknologi Bandung, Bandung, 40132, Indonesia

Abstract

© Published under licence by IOP Publishing Ltd.Our body contains 100 trillion cells. However, each cell has certain function and structure. For maintaining their integrity, cells will be collaborating with each other and with extracellular matrix surround them to form a tissue. These interactions effect internally on many networks or pathway such as signalling pathway, metabolic pathway and transport network in the cell. These networks interact with each other to maintain cell survival, cell structure and function and moreover the tissue as well as the organ which the cells built. Therefore, as part of a tissue, genetic and epigenetic abnormality of a cell can also alter these networks, and moreover disturb the function of the tissue itself. Hence, condition of genetic and epigenetic of the cell may affect other conditions in omics level such as transcriptomic, proteomic, metabolomics characteristics which can be differentiated by a particular unique molecular profile from each level, which can be used for diagnostic as well as for targeted therapy.

Author keywords

Cell structure,Cell survival,Extracellular matrices,Metabolic pathways,Metabolomics,Proteomic,Signalling pathways,Transport networks

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