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In vitro xanthine oxidase inhibitor activity of ethanol extract and fraction Roselle calyx (Hibiscus sabdariffa L.)
Wahyuningsih S.a,b, Sukandar E.Y.a, Sukrasnoa
a School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia
b Faculty of Pharmacy, UNJANI jalan Terusan Jenderal Sudirman, Cimahi, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© International Journal of Pharmaceutical and Clinical Research. All rights reserved.Objective: The objective of this study is to evaluate xanthine oxidase inhibitor activity of ethanol extract and fraction of roselle calyx (Hibiscus sabdariffa L) in vitro. Methods: The principle of measurement of xanthine oxidase activity inhibition is measuring the reduce of uric acid amount formed from the reaction catalyzed by xanthine oxidase, The uric acid is formed from the reaction between hypoxanthine and xanthine with xanthine oxidase enzyme. In this study allopurinol is use as reference drug. Result: The results showed that ethanol extract (100 μg/ml) can inhibit the activity of xanthine oxidase enzyme 25.13 %, water fraction inhibit 25.81% and the ethyl acetate fraction inhibit 32.25 %. with IC50 value of extract is 1294.37, IC50 water fraction 830.71 and IC50 value of ethyl acetat fraction is 290.62 μg/ml. Conclusion: Ethanol extract and fractions Roselle calyx have xanthine oxidase inhibitor activity with IC50 value of extract is 1294.37, IC50 water fraction 830.71 and IC50 value of ethyl acetat fraction is 290.62 μg/ml.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Antihyperuricemia,Extracts,Fractions,Hibiscus sabdariffa L,Xanthine oxidase[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]