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Evaluation of antifungal activity of a 3-extract formulation in topical dosage form and its safety aspect
Sukandar E.Y.a, Fidrianny I.a, Susanto E.a, Safitri D.a
a Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]� 2016, Innovare Academics Sciences Pvt. Ltd. All rights reserved.Objective: To determine the combination of extract of Rosmarinus officinalis leaves, Zingiber officinale rhizome, and Curcuma xanthorrhiza rhizome in 2 form topical preparations, cream, and ointment, through in situ study, as well as to evaluate safety aspect of both cream and ointment. Methods: Irritation skin and eye test were performed according to OECD guideline. Rabbits were also used as an object of the in situ study. A suspension of Trichophyton mentagrophytes was injected through the skin on both sides of rabbit’s back to induce dermatophytosis. Throughout the treatment period, topical preparation was applied to the infected site until the wound was fully recovered. Results: There was no significant irritation effect on both topical dosage forms. However, an incidence of redness was observed in the skin applied by cream. Healing rate of extract in ointment. Conclusion: Combination of the corresponding extract showed antifungal activity and was comparable to that of ketoconazole as a reference drug.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Curcuma xanthorrhiza rhizome,In situ,Irritation,Rosmarinus officinalis leaves,Zingiber officinale rhizome[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.22159/ajpcr.2016.v9s2.13551[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]