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The effect of electric field intensity, pulse width, and pulse rise time on conventional and supra electroporation
Sulaeman M.Y.a, Widita R.a
a Department of Physics, Nuclear Physics, Biophysics Research Division, Faculty of Mathematics and Natural Science, Institut Teknologi Bandung, Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2015 AIP Publishing LLC.Electroporation is formation of the pores in the membran cell due to external electric field applied to the cell. There are two types of electroporation, conventional and supra-electroporation. Both of them have a different characteristic of electric field used. Thus, the purpose of this research is to study the influence of the intenisty of electric field, pulse width, and pulse rise time given to the cell model and then compare the result of pores density formed. For both types, the electric field intensity ranged from 0.05kV/cm – 100kV/cm. For conventional electroporation, the pulse width and the rise time are constant at 1kV/cm and 2 microseconds. For supra-electroporation, the pulse width and the rise time are constant at 60kV/cm and 2 nanoseconds. As for variation in rise time, electric field intensity, and pulse width will be constant at 1kV/cm and 60 microseconds for conventional electroporation and 60kV/cm and 60 nanoseconds for supra-electroporation. The results showed that electric field intensity and rise time gave significant effects in transmembrane voltage and pores density. It can be concluded that the intensity of the electric field and the rise time greatly affect the electroporation phenomenon, although pulse width did not have any effect in transmembrane voltage and pore density.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.1063/1.4930766[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]