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Study of physical interaction mefenamic acid – Isonicotinamide
Yuyun Y.a,b, Nugrahani I.b
a Program Study of Pharmacy, Faculty of Mathematic and Natural Sciences, Tadulako University, Palu, Indonesia
b School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2015 AIP Publishing LLC.Solid-solid interaction in the form of physics and chemistry can occur in a combination of active ingredients with the active ingredient or active ingredients with excipients in a pharmaceutical preparation. Physical interactions can be classified into physical interaction system eutectic, peritectic, and molecular compounds based on the phase diagram of a mixture of two-component systems. The physical interaction between mefenamic acid and isonicotinamide not been reported previously. This study aims to examine the type of interaction of mefenamic acid (MA) with isonicotinamide (INA) and its interaction with the isolation methods by solvent drop grinding as the simplest method and easy to do. PXRD data showed the interaction of MA:INA mixture contained no new peaks, so the indicated MA:INA only form of eutectic interaction. There was founded new endothermic peak for DTA data at 149.5°C (SDG-Ethanol) and 148.4°C (SDG-EtAct). The results of infrared spectroscopy analysis indicated a shift in the NH stretch 3367cm-1 to 3359cm-1; and 3185cm-1 to 3178cm-1.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Co-crystal,Eutecticum,Mefenamic acid,Molecular compound,Physical interaction[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.1063/1.4930768[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]