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Inhibitory properties of panduratin A & 4-hvdroxvpanduratin A isolated from Kaempferiapandurata against some pathogenic bacteria
Marliayana S.D.a,b, Rukayadi Y.c, Ismail I.S.c, Mujaliidin D.a, Syah Y.M.a
a Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung, 40132, Indonesia
b Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Sebelas Maret, Indonesia
c Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia UPM, Serdang, Selangor Daml Ehsan, 43400, Malaysia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]Two ehalcone derivatives panduratm A (PA) (1) and 4-hydroxypanduratin A (4-HPA) (2) were isolated from the rhizome of Kaempferia pandurata Roxb, along with two flavanones pinostrobin (3) and pinocembrin (4). These compounds were screened for determining their growth inhibitory properties agamst nine bacterial pathogens: four Gram-(+) (Bacillus cereus ATCC 21772, Bacillus subtilis ATCC 663, Listeria monocytogenes ATCC 15313, and Staphylococcus aureus ATCC 29737) and five Gram-(-) (Escherichia coli 0157:H7, Klebsiella pneumoniae ATCC 13733, Proteous mirabilis ATCC 21100, Salmonella typhi ATCC 14028, and Vibrio parahaemoliticus ATCC 17802) bacteria. Hie results showed that only PA (1) and 4-HPA (2) exhibited significant inhibitory properties agamst these bactena. Further antibacterial test indicated that these two compounds were active against all the tested bacteria, with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values in the range of 1.2- 75 ng/mL and 2.3-150 fig/mL, respectively. The Gram-(-) bactena were found to be more affected by PA (1) and 4-HPA (2), and in general the antibacterial properties of PA (1) were two-fold higher than 4-HPA (2). Hence, PA (1) and 4-HPA (2) have the potential to be developed as new bioactive natural products that may serve as leads in new antimicrobial agents.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]4-hydroxypanduratin A,Antibacterial activity,Kaempferia pandurata,Panduratin A[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]