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Diuretic activity of matoa leaves extracts and fractions (Pometia pinnata J.R. Forster & J.G Forster) and its influence on potassium and sodium levels
Purwidyaningrum I.a,b, Sukandar E.Y.b, Fidrianny I.c
a Department of Pharmacology, Faculty of Pharmacy, Setia Budi University, Indonesia
b Pharmacology-Clinical Pharmacy Research Group, Indonesia
c Pharmaceutical Biology Research Group, School of Pharmacy, Bandung Institute of Technology, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2017 The Authors.Objective: The goal of this research were to determine diuretic activity of matoa leaves (Pometia pinnata J.R. Forster & J.G Forster) extracts and fractions and its influence on potassium and sodium levels. Methods: Matoa leaves were extracted by reflux method followed by evaporation using rotary evaporator. The subjects were male Wistar rats that were divided into 11 groups: Furosemide (3.6 mg/kg bw); control group carboxymethylcellulose 0.5%; matoa leaves extracts with doses of 50 mg/kg bw, 100 mg/kg bw, and 150 mg/kg bw; matoa leaves aqueous fraction with dose of 10.94 mg/kg bw, 21.88 mg/kg bw, and 32.82 mg/kg bw; matoa leaves ethyl acetate fraction (MEF) with dose of 4.35 mg/kg bw, 8.71 mg/kg bw, and 13.06 mg/kg bw. Rats were placed in metabolic cages during an observation study. Urine volume was measured for 5-24 hrs. Potassium and sodium levels in urine were determined using atomic absorption spectrophotometry. Results: The effective dose of matoa leaves extract and fractions for diuretic activity was matoa leaves MEF 8.71 mg/kg bw which could increase the excretion of sodium and potassium in the urine of the male Wistar rats. Conclusion: Matoa leaves extract and fractions could increase the excretion of sodium and potassium in the urine of the male Wistar rats.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Diuretic,Matoa (Pometia pinnata),Potassium levels,Sodium levels,Urine volume[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.22159/ajpcr.2017.v10s2.19481[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]