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Activity of karehau (Callicarpa longifolia lamk.) leaves ethanolic extract as a wound healing
Susilawati E.a, Aligita W.a, Adnyana I.K.a,b, Patonaha, Sukmawati I.K.a, Anneeshaa, Putria
a Department of Pharmacology, Bandung School of Pharmacy, Indonesia
b Department of Pharmacology and Toxicology, Bandung Institute of Technology, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2018, Pharmainfo Publications. All rights reserved.Wound is a condition where there is damage to normal tissue structure and function. This tissue damage may be accompanied by infection or not. Wound can be treated with the help of medicines. The Dayak Tunjung community in East Kalimantan has been used karehau leaves as a traditional medicine to treat wounds. The aim of this research was to evaluate the antibacterial and wound healing activity of karehau (Callicarpa longifolia Lamk.) leaves ethanolic extract and its gel preparation.This research was divided into several stages, that was an in vitro and in vivo anti-inflammatory activity evaluation, followed by antimicrobial activity evaluation, and lastly the wound healing activity evaluation on rabbit. The results showed that ethanol extract of kerehau leaf (Callicarpa longifolia Lamk.) had antibacterial activity with MCI 64 μg/mL in P. aeruginosa and S. Aureus. Whereas in bacterial infected wounds, there was a decrease in erythema score on day 9 and decreased pus on day 6. Ethanol extract of kerehau leaves gel with concentration of 5%, 10%, 20% had significant difference with negative control in wound healing. This preparation with concentration of 5%, 10%, 20% showed wound healing activity on days 10, 9, 7; respectively. It was concluded that the ethanol extract of kerehau leaves had the antibacterial and wound healing activity.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Antibacterial activity,Callicarpa longifolia Lamk,Kerehau leaves,Wound healing activity[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]This research was fully supported by The Ministry of Research, Technology, and Higher Education Republik of Indonesia.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]