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Wound healing in vivo and in vitro study of binahong leaves (Anredera cordifolia (Ten.) Steenis) and pegagan (Centella asiatica (L.) urban) ethanolic extract
Sutrisno E.a,b, Sukandar E.a, Fidrianny I.a, Adnyana I.K.a
a Pharmacology Clinical Pharmacy Research Group, School of Pharmacy Bandung Institute of Technology, Bandung, Indonesia
b Bandung School of Pharmacy, Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2018, SILAE (Italo-Latin American Society of Ethnomedicine). All rights reserved.Anredera cordifolia and Centella asiatica are the traditional medicinal plant used to treat several diseases in Southeast Asia countries. The objectives of this research were to evaluate the activities of these two plants extracts-based ointment and its combination as a wound healing in diabetic-induced rabbits. This study was performed by in vivo method as wound healing in diabetic-induced rabbits. Morton-Malone’s method was used to produce a wound in rabbit. The observation parameters was included decreasing in erythema scores, swelling score and wound diameter. The in vitro method was carried out using cell proliferation method. The in vivo study showed that binahong, pegagan extracts-based ointment and its combination had ability to decrease of erythema scores, swelling vast, and wound vast in diabetic-induced rabbits comparable to standard drug. In vitro study revealed that Anredera cordifolia and Centella asiatica increased the proliferation of fibroblast cell comparable to standard drug. Anredera cordifolia, Centella asiatica extract-based ointment and its combination had the ability to promote wound healing in diabetic-induced rabbits. The mechanism was by increasing the proliferation of fibroblast cell.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Anredera cordifolia,Centella asiatica,Diabetes mellitus,Proliferation cell,Wound healing[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]