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Alpha mangostin and xanthone from mangosteen (Garcinia mangostana L.) role on insulin tolerance and PPAR-γ in preclinical model diabetes mellitus
Ratwita W.a, Sukandar E.Y.a, Kurniati N.F.a, Adnyana I.K.a
a Department of Pharmacology and Toxicology, School of Pharmacy, Bandung Institute of Technology- Jenderal Achmad Yani University, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2018 Lifescience Global.Objective: This research elaborated role of alpha mangostin and xanthone on insulin resistance and peroxisome proliferator-activated receptor (PPAR)-γ by measuring blood glucose level and PPAR- γ expression on adipocyte cell culture. Methods: Insulin tolerance test were conducted using male wistar rat divided into 9 groups, which were normal, control (D-Glucose induced only), glibenclamide, various doses of α-mangostin and xanthone (5, 10, 20 mg/kgbw). All group induced by D-glucose 3 g/kg orally 30 minutes later. Blood glucose levels changes were observed at 90th and 150th minute. While other study observed PPAR-γ expression on adipocyte cell culture that treated with α- mangostin/xanthone/pioglitazone in various concentration. Results: KITT in all treatment groups were significantly different (p < 0.05) when compared to the positive control group, except xanthone 5 mg/kgbw. This suggests that α-mangostin 5, 10 and 20 mg/kgbw, xanthone 10 and 20 mg/kgbw, as well as metformin, have the effect of lowering insulin resistance in white rats given a 10-day fatty emulsion. Almost similar with thiazolinedione, alpha mangostin and xanthone increase PPAR-γ expression in adipocyte when the concentration bigger. But xanthone effect not as good as α-mangostin or thiazolinedione effect. Conclusion: Alpha mangostin and xanthone are two substances that showed potential effect to improve insulin tolerance by increasing PPAR-γ in adipocyte.[/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Author keywords" size="size-sm" text_align="text-left"][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Indexed keywords" size="size-sm" text_align="text-left"][vc_column_text]Insulin tolerance,PPAR-γ,Thiazolinedione,Xanthone,α-mangostin[/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="Funding details" size="size-sm" text_align="text-left"][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=".vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}"][vc_empty_space][megatron_heading title="DOI" size="size-sm" text_align="text-left"][vc_column_text]https://doi.org/10.6000/1927-5951.2018.08.03.1[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]