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Synthesis, crystal structures, and superoxide dismutase activity of two new multinuclear manganese(III)-salen-4,4′-bipyridine complexes
Deawati Y.a, Onggo D.a, Mulyani I.a, Hastiawan I.b, Kurnia D.b, Lonnecke P.c, Schmorl S.c, Kersting B.c, Hey-Hawkins E.c
a Inorganic and Physical Chemistry Research Group, Faculty of Mathematics and Natural Sciences, Institut Teknologi, Bandung, Indonesia
b Physical and Inorganic Chemistry Laboratory, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Indonesia
c Institut für Anorganische Chemie, Fakultät für Chemie und Mineralogie, Universität Leipzig, Germany
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2018 Elsevier B.V.Manganese(III)-salen complexes have been reported as superoxide dismutase mimics (mSOD) that can scavenge superoxide anion radicals. They are mononuclear complexes with a variety of salen ligands. Here, two new multinuclear manganese(III)-salen complexes with 4,4′-bipyridine (4,4′-bpy) as bridging ligand and ClO4− as axial ligand or PF6− as counter anion, respectively, are reported. The dimeric complex [{Mn(ClO4)(salen)}2(μ-4,4′-bpy)] (1) was obtained from [MnCl(salen)]·2H2O and 4,4′-bipyridine which followed by addition of NaClO4. While the polymeric complex {[Mn(salen)(4,4′-bpy)]PF6}n (2) was prepared by the same procedure of 1, followed by addition of KPF6 replacing NaClO4. Compounds 1 and 2 were characterized by elemental analysis, conductometry, infrared spectroscopy, electrospray-ionization mass spectrometry, and room temperature/variable temperature magnetic susceptibility measurements. The crystal structures of compounds 1 and 2 were determined by single crystal X-ray crystallography. Furthermore, in indirect SOD tests using riboflavin photoreduction, the polymeric compound 2 shows the slightly higher SOD activity with an IC50 of 1.6 ± 0.2 µM than the dimeric compounds 1 with an IC50 of 2.0 ± 0.3 µM.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Bipyridines,Dimeric,Mimic,Photo-reduction,Polymeric,Riboflavin,Super oxide dismutase[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Dimeric,Manganese-salen-4,4′-bipyridine,Mimic,Photoreduction,Polymeric,Riboflavin,SOD,Superoxide dismutase[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]This study was supported by a scholarship of BPPDN 2013, a scholarship of Sandwich-like Program (PKPI) 2015, and Doctoral Grants 2017 (No. 006/ADD/SP2H/LT/DRPM/VIII/2017 from the Directorate Generale of Higher Education, Republic of Indonesia. We would like to thank Dr. Debbie S. Retnoningrum from the Pharmaceutical Biotechnology Laboratory, School of Pharmacy, Institut Teknologi Bandung, for support with the SOD-like assays.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.1016/j.ica.2018.06.018[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]