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Preparation and release behavior of carboxylated cellulose nanocrystals-alginate nanocomposite loaded with rutin
Asri L.A.T.W.a, Rahmatika A.a,b, Fahreza M.Z.a, Insanu M.a, Purwasasmita B.S.a
a Materials Engineering Study Program, Bandung Institute of Technology, Bandung, 40132, Indonesia
b Bandung Institute of Science and Technology, Bekasi, 17530, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2018 IOP Publishing Ltd.Cellulose nanocrystals-alginate (CNC-ALG) nanocomposites were prepared as drug carriers for rutin. CNC was extracted from pineapple leaf fibers using ammonium persulfate to result in whiskers morphologies comprising carboxylate functional groups. Resulting CNC was combined with alginate and crosslinked with Ca2+ to form blank CNC-ALG with concentration of 0.1% and 0.2% w/v. Scanning electron microscopy images displayed sphere morphologies of blank CNC-ALG 0.1% with diameter of 136-302 nm, whereas blank CNC-ALG 0.2% has diameter of 224-555 nm with some irregular layered structure. Modification of blank CNC-ALG with chitosan resulted in irregular layered structure that has lower swelling degree than blank CNC-ALG in phosphate buffer saline solution at pH 7.4. Blank CNC-ALG 0.1% and 0.2% were loaded with rutin, with drug loading accounted 7.51% and 16.99% respectively. The CNC-ALG 0.1% and 0.2% showed sustained release properties of rutin in PBS pH 7.4 after 60 min, confirmed by the swelling behavior of blank CNC-ALG.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Carboxylate functional groups,Cellulose nano-crystals,Layered Structures,Phosphate buffer salines,Pineapple leaf fiber,rutin,Scanning electron microscopy image,Sustained release[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]alginate,cellulose nanocrystals,drug delivery,nanocomposite,rutin,sustained release[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]We gratefully acknowledge financial support from the Postdoctoral National-ITB Program, World Class University Grant, Indonesian Ministry of Education and Technology 2017. We thank Viny Veronika Tanuwijaya for assistance with SEM measurements.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.1088/2053-1591/aad5d3[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]