Fabrication of Scaffold based on Chitosan – Poly-2-Acrylamido- 2-Methylpropane Sulfonic Acid (PAMPS) Polyelectrolyte Complexes
Wibowo A.a, Mumtaziaha, Asri L.A.T.W.a, Qulub F.a, Mahyuddin A.I.a, Dirgantara T.a, Suratman R.a
a Material Science and Engineering Research Group, Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung, Bandung, Indonesia
Abstract
© Published under licence by IOP Publishing Ltd.Chitosan is considered as one of the best biopolymers for bone tissue engineering application due to its appealing properties such as biocompatible, non-toxic, non-immunogenic, able to accelerate growth rate of bone tissue, possess antibacterial activity and able to form porous structure. Herein, polyelectrolyte complexes (PECs) prepared by simple mixing of chitosan solution and poly-2-acrylamido-2-methylpropane sulfonic acid (PAMPS) solution were investigated. In this study, chitosan concentration were varied from 1.0 to 2.0% (w/v), while concentration of AMPS was fixed at 0.1% (w/v) to know the influence of chitosan concentration on swelling capacity and mechanical properties of obtained PECs. Swelling test and compressive test results showed that the most stable PECs in aqueous environment with highest ultimate compressive strength was PECs obtained from chitosan 2.0% (w/v) – PAMPS 0.1% (w/v) with swelling capacity 3,326% for 2 hours and ultimate compressive strength 1.22 kPa.
Author keywords
Anti-bacterial activity,Bone tissue engineering,Cancellous bone,Chitosan concentration,Polyelectrolyte complexes,Sulfonic acid,Swelling capacities,Ultimate compressive strength
Indexed keywords
cancellous bone implant,chitosan,poly-2-acrylamido-2-methylpropane sulfonic acid,polyelectrolytes complexes,tissue engineering
Funding details
This research was supported by International Collaboration Fund 2017 from Institut Teknologi Bandung.