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In situ functionalization of gadolinium oxide nanoparticles with polyethylene glycol (PEG) by pulsed laser ablation in a liquid medium (PLAL)
Dougherty A.a,b,c, Harper C.c, Iskandar F.a, Arif I.a, Dougherty G.c
a Department of Physics, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung, 40132, Indonesia
b Department of Physics, Faculty of Science and Technology, Nusa Cendana University, Kupang, 85001, Indonesia
c Applied Physics and Medical Imaging, California State University Channel Islands (CSUCI), Camarillo, 93012, United States
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2018 The AuthorsGadolinium oxide (Gd2O3) nanoparticles with paramagnetic properties and biocompatible surfaces are promising materials for bioimaging applications. We synthesized in situ pegylated Gd2O3 (Gd2O3@PEG) nanoparticles by liquid phase pulsed laser ablation (PLAL) of a gadolinium target in a polyethylene glycol (PEG) liquid medium. We characterized their shape and morphology using transmission electron microscopy (TEM), and confirmed their crystalline structure with X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) in combination with energy-dispersive X-ray spectroscopy (EDX) elemental mapping. The magnetic properties of the nanoparticles were characterized by vibrating sample magnetometry (VSM). We have found that the crystalline nanoparticles generated have a spherical shape and a narrow distribution with average diameters of 15.0, 11.6, and 6.0 nm, for PEG concentrations of 0.01, 0.05, and 0.10 mM, respectively. We verified that partially oxidized molecules of PEG are attached to the nanoparticle surface as carboxyl groups. An analysis of the magnetization of Gd2O3@PEG nanoparticles revealed highly paramagnetic properties. Consequently, PLAL forms a green synthesis of Gd2O3@PEG, opening up new opportunities for bioimaging applications.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Biocompatible,Functionalization,Gadolinium oxide,Nanoparticles,Pulsed laser ablation,Synthesis[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]The work was partially supported by the PKPI Sandwich-Like 2016 program from the Directorate General of Higher Education and Ministry of Research and Technology , Indonesia, an ITB Research and Innovation Grant 2016, and by Applied Physics, California State University Channel Islands. The authors would to thank Dr. Amanda Strom (Material Research Laboratory, University of California, Santa Barbara) for assisting us with the XRD, XPS, and VSM measurements and providing useful comments related to the interpretation.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.1016/j.jsamd.2018.08.003[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]