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Chemical Constituents of Pestalotiopsis microspora HF 12440
Riga R.a, Happyana N.a, Hakim E.H.a
a Natural Products Research Laboratory, Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology, Bandung, Indonesia
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2019 Riga Riga et al. Phytochemical investigation on the liquid media of Pestalotiopsis microspora HF 12440, an endophytic fungus isolated from the stem of Artocarpus heterophyllus, led to the isolation of three lactones, (+)-acetylpestalotin (1), (-)-pestalotin (2), (6S,7S,8R)-hydroxypestalotin (3) and a lignan, (+)-pinoresinol (4). Interestingly, one of them (1) is a new compound, while compound 4 is reported for the first time from endophytic fungi. Structures of the isolated compounds were determined based on spectroscopic data, including MS, NMR 1D and 2D. Cytotoxic values of the crude extract and all isolated compounds were evaluated against P388 cells, showing that compound 3 was the most active with IC 50 3.34 μg/ml. Overall, this is the first phytochemical report of endophytic fungi isolated from the host plant Artocarpus.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Artocarpus heterophyllus,Lactones,Lignan,Pestalotiopsis microspora[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text]PMDSU Scholarship (Ministry of Research, Technology and Higher Education of Indonesia) for financial support (grant number: 1511/E4.4/2015); Indonesian Institute of Science for the identification of endophytic fungus; Prof. Dr. Yana Maolana Syah and Dr. Elvira Hermawati for their aid in obtaining the NMR and mass spectra at the Bandung Institute of Technology.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.7324/JAPS.2019.90116[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]