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Phenalenones from a marine-derived fungus Penicillium sp.
Park S.C.a, Julianti E.a,b, Ahn S.a, Kim D.a, Lee S.K.a, Noh M.a, Oh D.-C.a, Oh K.-B., Shin J.a
a Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, 151-742, South Korea
b School of Pharmacy, Bandung Institute of Technology, Bandung, 40132, Indonesia
c Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, Seoul, 151-921, South Korea
[vc_row][vc_column][vc_row_inner][vc_column_inner][vc_separator css=”.vc_custom_1624529070653{padding-top: 30px !important;padding-bottom: 30px !important;}”][/vc_column_inner][/vc_row_inner][vc_row_inner layout=”boxed”][vc_column_inner width=”3/4″ css=”.vc_custom_1624695412187{border-right-width: 1px !important;border-right-color: #dddddd !important;border-right-style: solid !important;border-radius: 1px !important;}”][vc_empty_space][megatron_heading title=”Abstract” size=”size-sm” text_align=”text-left”][vc_column_text]© 2019 by the authors.Six new phenalenone derivatives (1–6), along with five known compounds (7–11) of the herqueinone class, were isolated from a marine-derived fungus Penicillium sp. The absolute configurations of these compounds were assigned based on chemical modifications and their specific rotations. 4-Hydroxysclerodin (6) and an acetone adduct of a triketone (7) exhibited moderate anti-angiogenetic and anti-inflammatory activities, respectively, while ent-peniciherqueinone (1) and isoherqueinone (9) exhibited moderate abilities to induce adipogenesis without cytotoxicity.[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Author keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Adipogenesis,Adiponectin,Angiogenesis Inhibitors,Anti-Inflammatory Agents,Aquatic Organisms,Cell Line,Human Umbilical Vein Endothelial Cells,Humans,Mesenchymal Stem Cells,Penicillium,Phenalenes[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Indexed keywords” size=”size-sm” text_align=”text-left”][vc_column_text]Adipogenesis,Anti-angiogenesis,Anti-inflammatory,Herqueinones,Marine-derived fungi,Penicillium sp,Phenalenones[/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”Funding details” size=”size-sm” text_align=”text-left”][vc_column_text][{‘$’: ‘This study was supported by the National Research Foundation (NRF, grant No. 2018R1A4A1021703) funded by the Ministry of Science, ICT, & Future Planning, Korea. We thank the Basic Science Research Institute in Daegu, Korea, for providing mass spectrometric data.’}, {‘$’: ‘Funding: This study was supported by the National Research Foundation (NRF, grant No. 2018R1A4A1021703) funded by the Ministry of Science, ICT, & Future Planning, Korea.’}][/vc_column_text][vc_empty_space][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][vc_empty_space][megatron_heading title=”DOI” size=”size-sm” text_align=”text-left”][vc_column_text]https://doi.org/10.3390/md17030176[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/4″][vc_column_text]Widget Plumx[/vc_column_text][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row][vc_column][vc_separator css=”.vc_custom_1624528584150{padding-top: 25px !important;padding-bottom: 25px !important;}”][/vc_column][/vc_row]